The film stars Akshay Kumar, John Abraham, Deepika Padukone and Chitrangada Singh[4] while Sanjay Dutt features in an extended cameo.

[5] The film was released on 25 November 2011, received a mixed response from critics and was declared an average at the box office.

The story follows two friends and roommates, the Gujarati rebel Jignesh 'Jerry' Patel and clean simpleton Nikhil 'Nick' Mathur, who live in London.

Nick intends to marry his girlfriend, Radhika Awasthi, who dreams of a lovely wedding, a great honeymoon, and a wonderful house to live in after marriage.

It is to tide over the difficult times that Jerry and Nick turn to the oddest profession in the world as they become escorts for a company owned by one Mr. Khalnayak, fulfilling the fantasies of girls and ladies.

Nonetheless, once their covers are blown, the ill-fated happens: Jerry is unable to prevent Veer from being sent to a foster home, and Nick loses Radhika when she learns of what he has been up to while she is away in India.

Frustrated, Nick blames Jerry for forcing him into the profession and asks him to move out of his house and life, thus causing a rift in their friendship.

The economy improves and everyone is happy in the end; in a short-ending scene, a newspaper article is shown stating that the recession will strike back when Mr. Khalnayak gives a call and says that he has obtained the license for a branch in Mumbai.

However, he praised the chemistry of the lead actors, commenting that "the camaraderie between Akshay and John is piping hot".

"[22] Subhash K. Jha gave the film 3.5 out of 5 Stars calling "highly entertaining sex comedy movie having Smart, sassy, sexy and sparkling with dark audacious humour".

[29] The film's songs were composed by Pritam Chakraborty and the lyrics were penned by Irshad Kamil, Kumaar & Amitabh Bhattacharya.

Furthermore, he chose Subha Hone Na De, Allah Maaf Kare, Make Some Noise For The Desi Boyz and Jhak Maar Ke as favorite picks.

[31] Glamsham gave the music a rating of 4 out of 5 saying, "Pritam builds up a good tempo in Make Some Noise For The Desi Boyz and carries the fun promisingly with Jhak Maar Ke and Tu Mera Hero with an all-together new breed and genre of music.

On 22 December 2022, Producers Anand Pandit and Parag Sanghvi announced the sequel titled Desi Boyz 2 with Eros International.