He played part of one season in Major League Baseball for the San Francisco Giants in 1996, primarily as a first baseman.

Desi Wilson played basketball and baseball for Fairleigh Dickinson University.

In 2005, while playing for the Surprise Fightin' Falcons, Desi had a 30-game hitting streak and batted .411, setting a Golden Baseball League record.

[citation needed] In 2007, Wilson began the season as the manager of the Anderson Joes of the independent South Coast League.

He was then traded to the South Georgia Peanuts where he served as a player-coach for the remainder of the season and was part of the club's SCL championship.