The debut titles under the Desperado/Image publishing partnership were Bob Burden's Flaming Carrot and a specially priced preview book, Desperado Primer, which gave readers a chance to sample the talent assembled under the Desperado umbrella.
(The Desperado Primer featured stories written by Paul Jenkins, with art by Adam Hughes, Brian Stelfreeze, Cully Hamner, Phil Hester, Kelsey Shannon, and Jason Pearson, and a prologue to Tony Harris's Roundeye).
In January 2005 they published Freak Show, a hardcover compilation of four vintage horror comics stories by the team of artist Bernie Wrightson & writer Bruce Jones.
In addition, Pruett and Desperado revived Negative Burn, starting with two seasonal specials in 2005, and segueing into a monthly title in 2006.
In addition to the aforementioned Burden, Harris, Hester, Jenkins, and Stelfreeze; notable creators involved with Desperado include Brian Bolland, P. Craig Russell, Andrew Robinson, Joe Jusko, Michael Gaydos, Tim Bradstreet, Goran Sudzuka, John McCrea, J.M.