Papamichail made her WTA Tour main-draw debut as a lucky loser at the 2021 Abu Dhabi Open, losing to third seed Karolína Plíšková in the first round.

[3] Papamichail qualified for the 2023 Pan Pacific Open and defeated lucky loser Sakura Hosogi,[4] before going out in the second round against sixth seed Daria Kasatkina.

[5] She won her first WTA125 doubles title at the 2023 Barranquilla Open, partnering with Valentini Grammatikopoulou to defeat Yuliana Lizarazo and María Paulina Pérez García in the final.

[8] She defeated Maria Mateas[9] to reach the second round at the 2024 Țiriac Foundation Trophy, where she lost to Kathinka von Deichmann.

[10] Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup/Billie Jean King Cup and Olympic Games are included in win–loss records.