Despotovac (Serbian Cyrillic: Деспотовац) is a town and municipality located in the Pomoravlje District of central Serbia.

Its name stems from Despot, a title of Serbian medieval prince Stefan Lazarević.

The Serb Orthodox monastery of Manasija was built between 1406[3]-1418 and is one of the most significant monuments of Serbian culture, belonging to the "Resava school" (Serbian architecture) From 1929 to 1941, Despotovac was part of the Morava Banovina of the Kingdom of Yugoslavia.

As of 2011 census results, the municipality had 22,995 inhabitants.

The ethnic composition of the municipality:[4] Aside from the town of Despotovac, the municipality includes the following settlements: The following table gives a preview of total number of employed people per their core activity (as of 2017):[6] This Pomoravlje District, Serbia location article is a stub.