Destanni Mone Henderson[1] (born February 2, 1999) is an American professional basketball player for Danilo's Pizza of the Turkish Super League.

She previously played for the Indiana Fever, Los Angeles Sparks, Phoenix Mercury, and Atlanta Dream in the Women's National Basketball Association (WNBA).

Henderson played college basketball for the South Carolina Gamecocks, helping her team win the national championship and earning first-team All-Southeastern Conference honors as a senior.

At Fort Myers Senior High School, she won three straight state titles, was a McDonald's All-American selection and was rated as the number one point guard in her class by ESPN.

Henderson competes for the United States national team and won a gold medal at the 2021 FIBA AmeriCup.

[7] As a sophomore, Henderson averaged 15.3 points, 4.3 assists, 3.5 rebounds and three steals per game,[8] and led her team to its first Class 6A state championship.

[6] She earned Class 6A All-State First Team honors and was selected as The News-Press All-Area Player of the Year.

[9][10] In her junior season, Henderson averaged 17.7 points, 4.3 assists and four rebounds per game, and helped Fort Myers win the Class 7A state title.

Henderson had received an offer from South Carolina in eighth grade, and was drawn there by head coach Dawn Staley.

[4][20] On November 11, 2018, Henderson made her debut for South Carolina, scoring 13 points in a 94–38 win against Alabama State.

[22] As a freshman, Henderson averaged 5.5 points and 1.3 assists per game, and was selected to the Southeastern Conference (SEC) All-Freshman Team.

[29] On March 7, she recorded 18 points and nine rebounds in a 67–62 victory over Georgia at the SEC tournament final, and was named to the all-tournament team.

[31] After being sidelined for three weeks, she returned on December 21, and posted 17 points, seven assists and a career-high seven steals in a 65–61 win over second-ranked Stanford.

In June 2023, Henderson signed with Turkish Women's Basketball Super League (KBSL) and EuroCup team Antalya BSB Toroslar BC.