Since 2004, over twenty-five editions of the game have been published, covering different geographic areas and including licensed versions inspired by Pixar animations, Harry Potter, the London 2012 Olympics, and Downton Abbey.

Among other obstacles, if players land on a traffic light, they must pick up a card, which can yield a range of outcomes, such as free fuel, a speeding fine, and licence points.

The game ends when the first student returns to their common room, which awards an extra 150 house points.

[5] In September 2004, Lowe appeared in the inaugural British series of Dragons' Den, pitching for £75,000 in return for a 35% stake in the company.

[14][15][16] Following the failure of the Dragons' Den pitch, RTL Games instead secured a loan from the Portsmouth Area Regeneration Trust Group's community development financial institution, which provided the prerequisite funding for marketing and additional stock.

[11][18] At a 2005 toy fair, Lowe struck a deal with Debenhams to stock Birmingham and Cardiff editions of the game.

[10][11] Destination South Africa featured website links and contact details for advertised businesses.

[21] Following a deal with The Walt Disney Company, RTL Games released the brand's first licensed edition.

[23][24] A Harry Potter–licensed edition of the game, Destination Hogwarts, was delayed after the film release of Harry Potter and the Half Blood Prince was postponed by eight months, missing the Christmas 2008 sales, and the bank refused RTL Games the necessary credit to cover the delay.

[5][28] In 2010, a BBC Panorama investigation on bank irresponsibility covered the demise of RTL Games Ltd. Angel investor Simon Dolan approached Lowe after her appearance in the documentary, and together they launched a new lifestyle company, She Who Dares UK Ltd, which acquired the Destination brand.

[35] While not part of the Destination brand, the gameplay is similar, with players planning routes to deliver babies across the board.

[18][39] Expected to launch in December 2023, the game will feature a double-sided board for day and night shifts.