[5] TNA released a poster featuring The Motor City Machine Guns (Alex Shelley and Chris Sabin; MCMG) sometime prior to help promote the event.

At Against All Odds, Rhino returned from injury to attack Storm during his encounter with Eric Young over the TNA World Beer Drinking Championship, reigniting their feud from mid-2007.

[11] This led to the two fighting at TNA's Victory Road PPV event on July 15, 2007, which Storm won.

[12] The two fought again at TNA's Hard Justice PPV event on August 12 in a Bar Room Brawl, which Storm also won.

[13] Rhino defeated Storm at TNA's No Surrender PPV event on September 9, 2007, thus ending the feud.

The feud regarding this contest began at Final Resolution, where Roode accidentally punched Booker T's wife Sharmell, fracturing her jaw in the storyline, after a Mixed Tag Team match pitting Roode and his then-manager Ms. Brooks against Booker T and Sharmell.

Due to pre-match stipulations, Team 3D was then forced to work with a weight-limit in TNA in order to compete in matches, with the limit set at 275 lb (125 kg).

[8] On the February 14 episode ofImpact!, Team 3D fought Curry Man and Shark Boy in which Ray did not make weight, leaving Devon to face them alone.

[15] On the February 21, 2008, episode of Impact!, another match was held between the teams, in which Devon did not make weight, but Ray still won the bout after cheating.

[10] The TNA Women's Knockout Championship was defended in a Three Way match by Awesome Kong against Gail Kim and ODB, also on the card.

Build to this encounter began on December 2, 2007, at TNA's Turning Point PPV event, where then-TNA Women's Knockout Champion Kim defeated Kong by disqualification.

[8] Leading up to Destination X, Kim and ODB started a partnership in order to try and take the championship from Kong on the February 14 episode of Impact!.

Andrew Thomas, Earl Hebner, Rudy Charles, and Mark "Slick" Johnson participated as referees for the encounters.

Besides employees appearing in a wrestling role, Salinas, Christy Hemme, Rhaka Khan, Scott Steiner, Sonjay Dutt, SoCal Val, Raisha Saeed, Jim Cornette, Johnny Devine, Payton Banks, Traci Brooks, and Jackie Moore all appeared on camera, either in backstage or ringside segments.

[21] The event opened with a Three Way Tag Team match to determine the number one contenders to the TNA World Tag Team Championship between The Latin American Xchange (Hernandez and Homicide; LAX), who were accompanied by Salinas, MCMG (Alex Shelley and Chris Sabin), and The Rock 'n Rave Infection (Jimmy Rave and Lance Hoyt), who were accompanied by Christy Hemme.

LAX won the bout thus becoming number one contenders after Hernandez pinned Rave following his signature Border Toss maneuver.

[22] Jay Lethal defended the TNA X Division Championship against Petey Williams, who was accompanied by Rhaka Khan, in a contest lasting eleven minutes and forty-one seconds.

Near the end of the bout, Khan distracted the referee, at which time Steiner came down to the ring and interfered in the match, allowing Williams to perform his signature Canadian Destroyer maneuver.

Later, Young returned to the ring dressed as a superhero, where he performed a double Death Valley Driver on Reign and Rellik slamming them both into the mat, thus winning the match.

[22] A Three Way match for the TNA Women's Knockout Championship was held in which then-champion Awesome Kong, who was accompanied by Raisha Saeed defended the title against Gail Kim and ODB.

Near the end, ODB was tripped by Saeed, which led to Kong performing her signature Awesome Bomb maneuver at eleven minutes and thirty-three seconds to win the contest.

Joe won the encounter after he forced Tomko to submit with his signature Coquina Clutch submission maneuver.

[27] Following Destination X, Samoa Joe went on to Lockdown on April 13, 2008, to face Kurt Angle in a Six Sides of Steel Cage match for the TNA World Heavyweight Championship.

[25] Christian Cage and Tomko were announced as the annual team captains in the 2008 Lethal Lockdown match by Cornette on the March 13 episode of Impact!.

[25] TNA X Division Champion Jay Lethal went on to defend the title in an Xscape match at Lockdown.

[28] The wrestlers who qualified for the bout were Shark Boy, Curry Man, Johnny Devine, Sonjay Dutt, and Consequences Creed.

[31] LAX (Hernandez and Homicide) became number one contenders to the TNA World Tag Team Championship at Destination X.

Young and Kaz won the bout, however, due to a controversial finish the championship was vacated by Cornette.

[31] Cornette then set up the Deuces Wild Tag Team Tournament heading into TNA's Sacrifice PPV event on May 11, 2008, to crown new champions.