The production on the album was handled by multiple producers including Smash David, CashMoneyAP, 808Melo, Cubeatz and OG Parker among others.

The album also features guest appearances from 6lack, Polo G, Fivio Foreign, Saweetie, Tyga, Toosii, Offset, and Moneybagg Yo.

Destined 2 Win was supported by six singles: "Losses", "Move On", "None of Your Love", "Calling My Phone", "Headshot" and "Born 2 Be Great".

Destined 2 Win is a hip hop album, incorporating elements of R&B, trap, emo rap and drill.

[7] Lil Tjay and 6lack performed their song "Calling My Phone" on The Tonight Show Starring Jimmy Fallon on April 5, 2021.

[13] The fourth single "Calling My Phone" was released on February 12, 2021, featuring American singer 6lack and was accompanied by a music video that premiered on the same day.

The fifth single "Headshot" was released on March 19, 2021, with frequent collaborator Polo G, and American rapper Fivio Foreign.

In an interview with Zane Lowe and Apple Music of how the song came together, Merritt said the collaborators meshed immediately.

Robin Murray of Clash Music praises Lil Tjay progression, calling the album a "A deft step outside of hood braggadocio".

Overall, Lilah believes Lil Tjay is manifesting his destiny, stating that "On Destined 2 Win, the young artist makes it known that this is a role he not only takes seriously, but one he plans to succeed in, no matter what.

"[21] Destined 2 Win debuted at number five on the US Billboard 200 chart, earning 62,000 album-equivalent units, (including 3,000 copies in pure album sales) in its first week.

[1] This became Lil Tjay's second US top ten debut on the chart, matching True 2 Myself which also peaked at number five.