Qin Feng (Liu Haoran) thought he was going to attend his distant uncle Tang Ren's (Wang Baoqiang) wedding, which turned out to be a hoax.

(the elements fire, water, wood, metal, and earth were used to determine the locations, date, and the respective organ to be removed) Finally, they find out that the doctor who was battling cancer believed that doing ancient Taoist rituals could grant him immortality, and was behind the murders.

Song Yi solved the case very early on and used the doctor's patterns to cover up his own murder of a sex trafficking ringleader who abducted his sister.

In addition of the two leads of Wang Baoqiang and Liu Haoran reprising their roles, new supporting cast members in Detective Chinatown 3 include Satoshi Tsumabuki, Tony Jaa, Tadanobu Asano, Masami Nagasawa, and Tomokazu Miura.

Premiering in January 2020, a web series starring Lin Mo (Roy Chiu) and Sa Sha (Zhang Yishang) expanded the Detective Chinatown universe.

In February 2024 a second season was also produced, featuring the return of Kiko (Yuxian Shang) from Detective Chinatown 2, who reprises her role as one of the main protagonists of the show.