[6] In their first season in the National Premier Soccer League (NPSL), Detroit City FC finished second in the five team Great Lakes Conference of the Midwest Region.

Le Rouge went on to lose 2–1 to AFC Cleveland in the Great Lakes Conference Semi-finals, ending their season with a 5–2–5 record.

Detroit City FC made its Lamar Hunt U.S. Open Cup debut on May 7, losing to RWB Adria in penalty kicks after a 2–2 draw.

In the NPSL regular season, the club claimed the Rust Belt Derby trophy for its second-straight year.

On March 10, Detroit City began roster announcements confirming the return of the 2015 Black Arrow MVP Dave Edwardson.

[10] Detroit City played its first home game in Keyworth on May 20, 2016, drawing 1–1 against AFC Ann Arbor in front of a then-record 7,410 supporters.

Despite starting the 2017 NPSL campaign with two points from three games, Detroit City went on a nine-game winning streak to finish second over-all in the Great Lakes Conference.

[16] Detroit ended its season in the NPSL national semi-finals with a loss on penalties against Midland-Odessa FC, from Texas, in front of a record crowd of 7,533.

[17] Early in 2018, original founder Ben Steffans left the ownership group and was replaced by Mike Lasinski[18] and Joe Richert, who was not outwardly announced or involved with running the club.

[20] The Fieldhouse included a "clubhouse" bar as well as two indoor soccer fields for fans and the local residents of Detroit.

[22] Detroit City finished first in the Midwest-Great Lakes conference for the 2019 season and was knocked out in the region finals by Cleveland SC on penalties.

[24] On August 15, 2019, the National Independent Soccer Association announced that Detroit City FC would join the NISA for the 2020 season.

[33] On May 16, 2024, the club announced plans to build a new soccer-specific stadium at the location of the abandoned Southwest Detroit Hospital near Corktown and Mexicantown.

Construction is slated to begin in the spring of 2025, and the club is hopeful that the stadium will be completed in time for the opening of the 2027 season.

On May 26, 2013, the club's match against Zanesville Athletic benefited the Wounded Warrior Project and Hooligans for Heroes, a nonprofit started by members of the Northern Guard Supporters.

On June 6, 2014, the club became the first American sports team to wear a uniform in support of LGBTQ inclusion in a regulation match.

Le Rouge dedicated the June 6 match versus Erie Admirals S.C. to inclusivity in sports, auctioning off the commemorative jerseys to benefit the Ruth Ellis Center, a Highland Park, MI., shelter for at-risk, runaway and homeless LGBTQ youth.

[48] These were typically high pressure games and particular fan favorites, especially by Detroit City FC supporter groups who have been known to greatly antagonize DCFC's opponents.

[51] AFC Ann Arbor was another rival of Detroit City prior to the two clubs leaving the NPSL and joining the USL League Two and NISA respectively.

City have generally played well against MLS opposition, including a 2−1 victory over Columbus Crew in the 2022 U.S. Open Cup.

They would later continue that rivalry with AFC Ann Arbor in 2021 after both teams moved to the newly returning USL W-League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.