The most powerful version, the 6-71, displaced 426 cubic inches (7.0 L) in total (71 cu in (1.2 L) per cylinder) and produced 170 hp (127 kW) at 1800 rpm.

While these engines with their low cost and relatively light weight were highly successful, there was also great demand for higher horsepower, especially for non-highway applications such as power generation and construction equipment.

One was to couple together multiple 6-71 engines in twin (side-by-side), tandem (fore-and-aft) and the quad (four 6-71s all driving a single shaft).

This resulted in the model 6-110, with 660 cubic inches (10.8 L) total displacement, which produced a continuous rating of 275 hp (205 kW) at 1800 rpm.

were all new, many of the additional components (injectors, governors, accessories, marine gears) were simply shared with the Series 71 engines.

The Series 110 was last produced in 1965, after which the manufacturing rights were purchased by the W. W. Williams Distribution Company, which continues to provide parts for these engines.

Other specifications include: Quoting from an introductory ad (Yachting Magazine, January 1951): "Here's the newest member of the General Motors Diesel family - the brawny 6-110 engine that develops 275 hp (205 kW).

The new engine, designated the "110" because of its 110 cubic inches (1.8 L) displacement per cylinder, is a 6-cylinder, 2-cycle unit rated at 275 hp (205 kW).

The new 110 engine embodies the same advanced principles of high-speed, two-cycle design as the 71 series, of which more than 45,000,000 horsepower have been produced by Detroit Diesel since 1937.

GM unit injectors (one for each cylinder) pump, meter and atomize the fuel, and are easily removed for inspection or exchange.

This symmetry allows the cylinder head and block to be reversed, giving a choice of rotational directions and making possible a variety of accessory locations to suit installation requirements.