A native of Regina, Saskatchewan, Dubnyk also played with the Nashville Predators and Arizona Coyotes before landing with the Minnesota Wild, with whom he enjoyed the most successful seasons of his NHL career.

[2] Dubnyk was called up by Edmonton early in the 2009–10 season after Oilers starting goaltender Nikolai Khabibulin underwent season-ending back surgery.

Dubnyk made his first NHL appearance on November 28, 2009, replacing Deslauriers in a 7–3 loss to the Vancouver Canucks, allowing three goals on 24 shots.

[8] He closed out his season by earning back-to-back wins against the Presidents' Trophy-winning Vancouver Canucks, stopping 46 of 47 shots against in the process.

[9] On October 9, 2011, Dubnyk started his first career season opener, defeating the Pittsburgh Penguins 2–1 in the shootout while stopping 35 shots in the process.

Dubnyk, however, struggled at the beginning of the 2011–12 season, recording four wins in his first 13 games along with a 3.03 GAA and a 0.902 save percentage, allowing Nikolai Khabibulin to temporarily reclaim the starter's role.

As Khabibulin began to struggle, however, Dubnyk reclaimed a large portion of Edmonton's starting opportunities, finishing with a strong second half to the season.

[10] Dubnyk, however, enjoyed relative success, ending the season with a 2.57 GAA and a .920 save percentage in 14 wins and 22 losses, his then-best career NHL statistics, sufficient to earn him a second year to be a starter.

[12] After starting in only two games as a Predator, Dubnyk was sent to the AHL's Milwaukee Admirals on March 3 to accommodate goaltender Pekka Rinne's return from long-term injured reserve.

Minnesota was eight points out of a 2015 playoff spot when Dubnyk made his Wild debut, a shutout victory over the Buffalo Sabres.

On April 24, Dubnyk was shortlisted as a finalist for the Vezina Trophy, along with Montreal's Carey Price and Nashville's Pekka Rinne for goaltender of the year honours.

During the 2019–20 season, Dubnyk struggled and lost the starting goaltending job to long time backup and Minnesota native Alex Stalock.

On April 10, 2021, Dubnyk was traded by the Sharks to add depth to the contending Colorado Avalanche in exchange for Greg Pateryn and a fifth-round pick in the 2021 NHL Entry Draft.

[25] As an unsigned free agent over the summer from the Avalanche, and into the commencement of the 2021–22 season, Dubnyk signed a professional tryout contract in the AHL, with the Charlotte Checkers, the primary affiliate to the Florida Panthers on December 7, 2021.

[32] Shortly after finishing his season with the Oilers in 2011–12, Dubnyk again was named to Canada's roster for the 2012 IIHF World Championship in Finland and Sweden.