Prince Devavongse Varoprakar was born in Bangkok's Grand Palace on 27 November 1858 to King Mongkut, Rama IV of Siam and Princess Consort Piyamavadi (Piam Sucharitakul).

At the age of 27, when Chao Phraya Phanuwongse Mahakosa Thobodi (Tuam Bunnag) had resigned, he was promoted to be the Minister of Foreign Affairs in which role he started to establish modern diplomatic methods and policies.

During the reign of King Vajiravudh, Rama VI of Siam, who was the child of his maternal younger sister, Queen Sri Bajarindra, the Queen Mother, he was delegated to work as the Head of the King's administration (Prime Minister) and was awarded the title of Krom Phra Devawongse Varoprakar, in 1911.

He was also delegated many positions of the royal court of King Rama VI such as the chairman of the minister council.

At the age of 64 Prince Devawongse died due to sepsis from a carbuncle (abscess), complicated by his diabetes, at Devavesma palace, his residence, on 28 June 1923.