He has played in Major League Baseball (MLB) for the Cincinnati Reds and New York Mets.

In that same year, he helped the Chucks win the PIAA Class AAA State Championship played at Peoples Natural Gas Field, home of the Altoona Curve.

[citation needed] Prior to the 2012 season, Mesoraco was ranked as the top prospect in the Reds organization according to Baseball America.

[8] He was added to the 40-man roster, played in the 2011 Futures Game, and brought up as a September call-up for the Reds in 2011.

On July 30, 2012, Mesoraco was ejected from a game against the San Diego Padres for arguing with umpire Chad Fairchild.

On January 26, 2015, the Cincinnati Reds and Mesoraco agreed to a four-year contract extension worth $28 million.

[16] Later on June 20, Mesoraco announced that he would undergo left hip surgery, causing him to miss the rest of the 2015 season.

On May 6, 2016, Mesoraco opted to have surgery on his left shoulder that was diagnosed with a torn labrum, causing him to miss the rest of the 2016 season.

On May 8, 2018, the Reds traded Mesoraco with cash considerations to the New York Mets for Matt Harvey.

On March 25, 2019, the New York Mets placed Mesoraco on their restricted list after he failed to make their Opening Day roster and he refused to report to his minor league assignment.

[20] On July 10, 2020, Mesoraco joined the University of Pittsburgh coaching staff as a volunteer assistant, working primarily with the catchers, officially ending his playing career.

Mesoraco married his longtime fiancée, Kira, on November 15, 2014, at St. Cosmas & Damian church in Punxsutawney.