In September 2015, he failed to catch on with the Toronto Maple Leafs after being initially signed to a professional tryout (PTO) contract during training camp.

In September 2016, he made the Los Angeles Kings out of training camp and signed a one-year, two-way contract for the 2016–17 season.

Setoguchi played one season with the now-defunct Crowsnest Pass Timberwolves of the Alberta Junior Hockey League (AJHL).

The following day, San Jose lost to the Detroit Red Wings 6–3, in which Setoguchi scored a powerplay goal.

On April 15, 2008, Setoguchi appeared in his first Stanley Cup playoff game, where he assisted on the game-tying goal in the third period.

[4] During the 2008–09 season, Setoguchi spent most of his ice-time with teammates Joe Thornton and Patrick Marleau on San Jose's first line.

[11] On November 27, 2014, after skating 12 NHL games with no points, Setoguchi cleared waivers and was assigned to the Adirondack Flames of the AHL.

On August 11, 2015, Glen Campbell of CTV Sports reported Setoguchi claims to have attended rehab and that he has been "clean and sober for five months" with hopes of signing with an NHL team.

[16] After a successful training camp and pre-season, Setoguchi was signed by the Kings to a one-year, two-way contract on the eve of the 2016–17 season on October 11, 2016.