He played college football for the LSU Tigers, and was selected by the Tampa Bay Buccaneers fifth overall in the 2019 NFL draft.

Devin White attended North Webster High School in Springhill, Louisiana where he played football as a standout linebacker and running back.

[13][14] White made his NFL debut in Week 1 against the San Francisco 49ers, making six tackles in the 31–17 loss.

[15] In Week 2, during a 20–14 win over the Carolina Panthers, White sprained his MCL which resulted in him missing the next three games.

[16] In Week 9 against the Seattle Seahawks, White recorded a team-high 12 tackles, half a sack on Russell Wilson, and two forced fumbles on running back Chris Carson, one of which that was recovered by teammate Jordan Whitehead in the 40–34 overtime loss.

[18] In Week 12, during a 35–22 win against the Atlanta Falcons, White recorded eight tackles and sacked Matt Ryan twice, the first multi-sack game of his career.

[20] As a result of White's strong play in November (39 tackles, 2.5 sacks, one pass deflection, and two forced fumbles from Weeks 9–12), he was named National Football Conference (NFC) Defensive Rookie of the Month.

[25] In Week 6 against the Green Bay Packers, White led the team with 10 tackles and sacked Aaron Rodgers once during the 38–10 win.