William Musgrave's publication De arthritide symptomatica (2nd edn, 1715) included the first scientific description of "Devonshire colic" – it was later referred to by John Huxham and Sir George Baker.
[1] However, the precise cause was not discovered until the 1760s when Dr George Baker put forward the hypothesis that poisoning from lead in cider was to blame.
He also conducted chemical tests to demonstrate the presence of lead in Devon apple juice.
The publication of his results met with some hostile reaction from cider manufacturers, keen to defend their product.
Once Baker's conclusions became accepted and the elimination of lead from the cider presses was undertaken, the colic declined.