Deweese is a village in Clay County, Nebraska, United States.

Deweese was platted in 1885 when the Burlington and Missouri River Railroad was extended to that point.

[6] According to the United States Census Bureau, the village has a total area of 0.13 square miles (0.34 km2), all land.

41.4% of all households were made up of individuals, and 6.9% had someone living alone who was 65 years of age or older.

42.9% of all households were made up of individuals, and 25.7% had someone living alone who was 65 years of age or older.

There were no families and 2.9% of the population living below the poverty line, including no under eighteens and none of those over 64.