The Dhaleshwari River (Bengali: ধলেশ্বরী, romanized: Dhalēśbarī , Dhôleshshori) is a distributary, 160 kilometres (99 mi) long, of the Jamuna River in central Bangladesh.

It branches off the Jamuna near the northwestern tip of Tangail District into a north branch that retains the name Dhaleshwari and merges with the other branch, the Kaliganga River at the southern part of Manikganj District.

Finally the merged flow meets the Shitalakshya River near Narayanganj District.

This combined flow goes southwards to merge into the Meghna River.

Water pollution of the Dhaleshwari River by the textile industry has been described by academics as an ecocide.