He made his acting debut in 2002 with the coming of age drama, Thulluvadho Ilamai, directed by his father Kasthuri Raja.
[7] In 2012, he received international attention with the song "Why This Kolaveri Di", which was recorded for Aishwarya R. Dhanush's directorial debut 3.
[13] In 2014, he produced and starred in cinematographer R. Velraj's directorial debut, Velaiilla Pattadhari,[14] which was critically acclaimed as well as a box-office success.
[17] The following year Dhanush played three roles in K. V. Anand's romantic thriller Anegan (2015) and a gangster in Balaji Mohan's Maari (2015), both becoming moderately success at the box office.
[18] Dhanush had two releases in 2016—Prabhu Solomon's Thodari, a critical and commercial failure;[19] and the political drama Kodi, where he played dual roles.