Frampton is the lead singer of the band Meg & Dia, was the runner-up in the inaugural season of The Voice, and is perhaps most known for her presence and collaborations in the EDM world, having worked with DJs such as Illenium and Kaskade among many others.

She cites Modest Mouse, Tom Petty and the Heartbreakers, Joni Mitchell, The Avett Brothers, Rocky Votolato, Ben Folds, Etta James, Death Cab for Cutie, The Cranberries, and Cursive as influences.

[2] During live performances, Frampton plays percussion instruments, such as the cowbell and tambourine, and occasionally a Casio Privia keyboard.

She explained, "It was something very raw, and to be honest, something that I was slightly embarrassed to put up because of the quality but I did anyways, for any of our listeners who would care to hear something not hot off the production belt, but something more organic and 'home made.'

Nonetheless, the band released their fourth studio album, Cocoon, which was received positively by fans and critics, but failed to perform well commercially, leading to Dia's manager, Mike Kaminsky, suggesting her audition for The Voice.

Dia Frampton was a contestant (and eventual runner-up) on the first season of The Voice on NBC, introduced as a children's story author.

Frampton stated that she had originally joined the show only with the intention of promoting Cocoon and had not expected that she would make it that far in the competition.

[5] Frampton subsequently won the title of Entertainment Weekly's 2011 'Favourite Reality Show Personality' over Michael Stagliano from the second season of Bachelor Pad.

[8] Her own solo US tour took place from February to July 2012,[9] with Canadian singer-songwriter Andrew Allen as her opening act.

[11] She covered the Korean song, "Lonely" by 2NE1, as an acoustic ballad in English for allkpop.com to promote her later concert in Seoul, Korea.

[13] In January 2013, Dia held a small tour, staging concerts across Southeast Asian countries Vietnam, Singapore, Philippines, Thailand, Malaysia and Indonesia.

These include Jason Ross, Witt Lowry, Illenium, Kaskade, tyDi, Dabin and Christopher Tin.

On July 26, the group (now a duo, with former guitarist Gimenez returning as a touring member) surprise-released their fifth studio album "happysad" through Pure Noise Records and released music videos for tracks "American Spirit" and "Teenagers".

In 2020, Frampton starred as the lead in the musical holiday romance film I Hate New Year's, with Ashley Argota as her co-lead and Candis Cayne.

In 2021, Frampton starred in the holiday romance film Christmas at the Ranch with Amanda Righetti, Lindsay Wagner, Laur Allen and Archie Kao playing the character Lauren.