She has hosted Mai dire Amici, a comedy show developed by Gialappa's Band for Italian television channel Canale 5.

[7] In March 2018 she starred in the comedy Puoi baciare lo sposo, directed by Alessandro Genovesi as well as in the movie La profezia dell'armadillo, based on the comic book by Zerocalcare.

Del Bufalo is currently part of the cast of real-life thriller, Celebrity Hunted: Caccia all'uomo, produced by Endemol Shine Italy and broadcast on Prime Video where she is paired with Cristiano Caccamo.

Between June 2020 and February 2021 she was involved in the filming of the sixth season of Che Dio ci aiuti, starring as Monica Giulietti.

After being in a relationship with singer Francesco Arpino,[10] from 2015 to 2019 she was involved with actor and director Paolo Ruffini, whom she met during her time hosting television show Colorado.