[1][2] From 1998 to 2003, Maffía served as deputy ombudsman of the City of Buenos Aires, in the area of human rights and gender equality.

From 2004 to 2008, she was academic director of the Hannah Arendt Institute of Cultural and Political Formation, and taught the classes "Scientific, Practical, Mystical, Aesthetic Knowledge" and "Social Contract Modes".

During her tenure, she introduced a bill to improve the conditions of sex workers,[5] spearheaded the creation of the Raquel Liberman Award for the prevention of gender violence,[6] supported the legalization of abortion in Argentina,[7] and co-authored a bill on dignified death.

[9][10] On 26 May 2012, she participated in the WikiGénero "making gender gaps visible on Wikipedia" meeting held at the Ricardo Rojas Cultural Center in Buenos Aires.

Other academic positions include professor of gnosiology at the UBA Faculty of Philosophy and Letters, professor of feminist epistemology (in the master of gender studies program) at the National University of Rosario's Faculty of Humanities and Arts, researcher at the UBA Interdisciplinary Institute for Gender Studies, and director of the study "Control, Defense, and Promotion of Sexual and Reproductive Rights", funded by the Ford Foundation.