[2] Muldaur's television roles include Rosalind Shays on L.A. Law and Dr. Katherine Pulaski in the second season of Star Trek: The Next Generation.

[4][6] She was at one point a board member of the Screen Actors Guild and was the first woman to serve as president of the Academy of Television Arts & Sciences (1983–1985).

She then did a five-episode arc as Jeannie Orloff in the final season of Richard Chamberlain's NBC medical drama Dr. Kildare.

Various roles as a guest star in episodes of numerous television shows followed, including Bonanza, I Spy, The Courtship of Eddie's Father, The Invaders, Mannix, Mod Squad, Hawaii Five-O, The F.B.I., The Virginian, a two-episode arc on the Ben Gazzara drama Run for Your Life, and as a guest star in 1975 in S.W.A.T.

During this time, a friendship with creator Gene Roddenberry formed that led to him casting Muldaur as Marg in the television film Planet Earth (1974) with John Saxon.

The soap, intended as a comeback vehicle for Hollywood star Lana Turner, was cancelled early into the 1970 television season after 15 episodes.

She also appeared in Sidney J. Furie's The Lawyer (1970), One More Train to Rob (1971) with George Peppard and the John Wayne crime drama, McQ (1974).

Muldaur appeared in the ensemble-apocalypse thriller Chosen Survivors (1974) with Jackie Cooper, Richard Jaeckel, and Barbara Babcock.

In 1977, she played Elaine Mati, the concerned wife of mentally unstable doctor Telly Savalas in the independent film Beyond Reason.

In 1971, she appeared as Rachel Bonham in The Men From Shiloh (rebranded name for the TV Western The Virginian) in the episode titled "The Politician".

In 1975, she made a guest appearance in an episode of The Rockford Files as Mrs. Bannister, a married woman who has an affair with a former cellmate of the series' title character.

Muldaur was cast as conservationist Joy Adamson in the television drama Born Free about Elsa the Lioness.

Filming for the ambitious project, which co-starred Gary Collins, took place in Kenya, and the NBC series, which debuted in the fall of 1974, lasted one season.

First an Emmy-winning miniseries and then a weekly drama, A Year in the Life was a critical success for NBC, with a cast including Richard Kiley and Sarah Jessica Parker.

Consequently, for the second season of Star Trek: The Next Generation, Roddenberry chose her specifically to replace the outgoing Gates McFadden (who was let go at the insistence of the show's first-season producer Maurice Hurley).

[4] Of Pulaski's willingness to stand up to the captain, Muldaur said We've been in a fairly stormy relationship due to two very strong personalities, but we end up admiring each other.

[4]Some television critics praised Muldaur's performance, with one noting her "wry, no-nonsense warmth that plays nicely off of some of the icier regulars".

[9] Ultimately, Muldaur found working on the syndicated show an "unhappy" experience, saying, "The imagination and joy wasn't there".

[15] Roddenberry described Muldaur as "a most talented actress" and said that the decision "to let her go was made solely because the hoped-for chemistry between her and the rest of the starship cast did not develop.

"[18] The "revolving door" and the limited opportunities for female crew led critics to suggest that the mostly male series still had a problem featuring women.

Of Roz's creation, by prolific television writer David E. Kelley, Muldaur said: We didn't think of her as an evil wench at the time.

[5] In one episode of the Stephen Bochco drama, Jill Eikenberry's character Ann Kelsey tells Shays: "If you were a man, you'd be applauded for your achievements.

In the early 1990s, she also guest-starred on two episodes of Matlock, as well as Empty Nest with Richard Mulligan and the pilot for Aaron Spelling's Hearts Are Wild.

In 1973, Muldaur co-starred in the television film Call to Danger as Carrie Donovon, a Justice Department investigator.

In an attempt to capitalize on Burt Reynolds' international superstardom, Muldaur's performance in the pilot episode of the Reynolds-Norman Fell crime series, Dan August (1970–1971) was edited together with a subsequent episode and repackaged as a 1980 ABC Movie of the Week titled Dan August: The Jealousy Factor.

Her other television films include the Black Beauty miniseries (1977), Pine Canyon is Burning (1977), Maneaters Are Loose!

(1978), The Word (1978), and Joseph Wambaugh's two-hour film Police Story: A Cry for Justice (1978) with Dennis Weaver and Larry Hagman.

Muldaur teamed with The Smothers Brothers for Terror at Alcatraz (1982) and turned in strong dramatic performances in Murder in Three Acts (1986) opposite Peter Ustinov and Locked Up: A Mother's Rage (1991) with Jean Smart and Angela Bassett.