Her role on Orange Is the New Black has contributed to three consecutive wins for the Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Comedy Series.

Guerrero is the author of In the Country We Love: My Family Divided, a memoir about her parents being detained and deported when she was fourteen.

Among her high school activities was singing with a jazz group, but she anticipated pursuing political science and communications in college.

[9] In 2011, she moved to New York City and studied acting at the Susan Batson Studios, where she met her manager Josh Taylor.

In 2012, Guerrero was cast in Orange is the New Black in the role of Maritza Ramos, a Bronx-bred character with Colombian roots.

[7][10] For season 2, she was part of the cast that earned recognition for Outstanding Performance by an Ensemble in a Comedy Series at the 21st Screen Actors Guild Awards.

[17][18] In February 2015, Guerrero was cast as the female lead in CBS' television pilot for Super Clyde,[19] but the show was not picked up for series.

[28] One of the main reasons she wanted to cater this book to a younger audience is because she felt like kids who were in similar situations as her own had no knowledge on how to deal with it.

[33][34] Guerrero provided the voice of Isabela Madrigal in the Disney animated film Encanto, which premiered November 24, 2021.

[38] She also became a board member for Mi Familia Vota, a national nonprofit organization that seeks to engage communities for social justice.