Following Les Misérables, Pilkington starred in the production of Tess, going on tour with the show prior to it appearing at the Savoy, she played the role of Marion.

Pilkington joined the cast of Sweeney Todd at the Bridewell Theatre later in 2000, a production she had played the role of Mrs Lovett in whilst training at GSA.

Again in 2003 Pilkington originated another role in the West End, this time in Rod Stewart musical Tonight's the Night, as Mary at the Victoria Palace Theatre.

For the Christmas panto season of 2004–2005 Pilkington starred in the leading role in Snow White and the Seven Dwarfs opposite Lily Savage.

After leaving the Cats tour in early 2007, Pilkington joined the West End production of Wicked at the Apollo Victoria Theatre.

Immediately after leaving Wicked, Pilkington played the parts of Annabella Schmidt, Pamela, and Margaret in the West End production of The 39 Steps.

[4] After leaving The 39 Steps Pilkington took part in a season of cabarets at Lauderdale House on 20 February 2011, performing many tracks from her album.

[6] She starred as Sophie De Palma in the West End production of Master Class, which ran at the Vaudeville Theatre from January – April 2012.

[11] Pilkington created the role of ‘Raquel’in the musical of Only Fools And Horses, written by Jim Sullivan and Paul Whitehouse.

Pilkington was credited as Inn Whore 1[17] appearing in the Master of the House scene opposite Helena Bonham Carter and Sacha Baron Cohen.

Pilkington's television credits include appearing on the West End edition of The Weakest Link, which aired 31 December 2008.