[1] Diaporthales includes a number of plant pathogenic fungi, the most notorious of which is Cryphonectria parasitica (Murrill) Barr, the chestnut blight fungus that altered the landscape of eastern North America.

Other diseases caused by members of this order include stem canker of soybeans (Diaporthe phaseolorum (Cooke & Ellis) Sacc.

Some species produce secondary metabolites that result in toxicosis of animals such as lupinosis of sheep (Diaporthe toxica P.M. Williamson et al.).

A number of asexually reproducing plant pathogenic fungi also belong in the Diaporthales, such Greeneria uvicola (Berk.

[2] The following genera within the Diaporthales have an uncertain taxonomic placement (incertae sedis), according to the 2007 Outline of Ascomycota.