McGuire was one of the premier guards of the 1950s, playing 11 seasons in the NBA (1949–60), eight with the New York Knicks and three with the Detroit Pistons.

McGuire led the league in assists during his rookie season with a then-record 386 assists,[2] and was among the league's top ten playmakers for ten of his 11 seasons.

[4] McGuire was working as a senior consultant for the Knicks when he died on February 3, 2010, of a ruptured aortic aneurysm at age 84.

They are the only pair of brothers inducted into the Naismith Memorial Basketball Hall of Fame.

McGuire was inducted into the Suffolk Sports Hall of Fame on Long Island in the Basketball Category with the Class of 1994.