He spent the majority of his playing career in the top two divisions of French football with Marseille, Bastia, Toulouse and Lille.

In the 2001–02 season, he had a spell with Scottish Premier League side Livingston.

[4] Santini was appointed head coach of Stade Briochin in 2021, but was dismissed from his duties in September 2022.

[5] In November 2022, Santini took charge of Rodez AF, at the time in the relegation zone of Ligue 2.

This biographical article related to association football in France, about a defender born in the 1960s, is a stub.