Diego Armando Calderón Espinoza (born October 26, 1986) is an Ecuadorian footballer.

He was part of the squad who won the 2008 Copa Libertadores with Liga de Quito.

However, he sustained an injury during the Round of 16 and was replaced by Renán Calle for the rest of the tournament.

Calderón again became a regular starter during Liga's campaign in the 2008 FIFA Club World Cup.

Although Liga was able to defeat Pachuca 2–0 in the semifinals, they lost the final to Manchester United, 1–0.