Diego was praised for his performance under president Adolfo Díaz from both conservative and liberal politicians.

Don Diego was elected President of Nicaragua in 1921, following his nephew Emiliano in that office.

His government faced hard times with questions of electoral fraud, and lack of legitimacy.

[3] The war had a negative impact on the Nicaraguan economy, which was in deep recession since his taking oath of office.

[citation needed] President Diego Manuel Chamorro died in office in 1923, in Managua, aged 62.