Diego Quispe Tito, adopted a distinctive style blending Italian Mannerism and Flemish painting techniques with depictions of local landscapes adorned with decorative birds.

Working in a village near Cuzco, Quispe Tito developed his unique approach, exemplified in his series of paintings portraying the life of St. John the Baptist for the Church of San Sebastian in 1663.

[2] The son of a noble Inca family, Quispe Tito was born in Cuzco, and worked throughout his life in the district of San Sebastián; his house remains, and shows his coat of arms on its door.

Quispe Tito's earliest signed painting is an Immaculate Conception from 1627, gilded in a fashion typical of the Cuzco school.

Quispe Tito also incorporated several personal elements into his work; most notable was his use of gilding and his depiction of spacious landscapes filled with birds and angels.