[2][3] The works of de Siloé combine the Italian Renaissance style that he had studied on a visit to Naples around 1517 with the influences of the Spanish Gothic and of Arab architecture in Spain.

The monumental staircase splits into two sections parallel to the back wall, and incorporates architectural elements of the classicist tradition, in the style of the Italian architect Donato Bramante.

The elevations show references to the work of Filippo Brunelleschi, with large pillars fronted by Corinthian half-columns, matching the height of the naves, with a second body of supports over the entablature of the first.

Among his other most notable projects are the Sacra Capilla de El Salvador del Mundo ("Holy Chapel of the Savior of the World") in Úbeda, conceived as a burial place for the Cobos family.

He was also the sculptor of a notable tomb in Spain's Basque Country, the mausoleum of Bishop Rodrigo Mercado de Zuazola, who was president of the chancery of Granada.