[1][2] The WMA covers a 40-acre (16 ha) tract of marshy woodland, with two man-made ponds ('impoundments') for wildlife, located between Chesapeake & Ohio Canal towpath (mileposts 20.08 to 20.90[3]) and the Potomac River.

Unlike most WMAs in Maryland, Dierrsen is a wildlife sanctuary - no hunting is allowed, but hiking and photography are encouraged.

Because of the impoundments and location on the Potomac migration route, the tract is a well-known habitat for waterfowl, wading birds and songbirds.

Also present are white-tailed deer, gray and red fox, beaver, and wild turkeys.

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