It has seen use in Australia,[6] Europe, and in Feb 2024 registered in North America by the PMRA, EPA registration pending, for use on soybean and corn.

Diflufenican rapidly metabolises in cereals to carbon dioxide via nicotinamide and nicotinic acid, and leaves no detectable residue after 200–250 days.

[3] Targeted weeds display bleaching and chlorotic spotting, followed by pink and purple foliage and necrosis.

[11] Diflufenican inhibits carotenoid synthesis, without which photosynthesis begins to fail and the plant is vulnerable to damage from sunlight, causing growth cessation and necrosis.

[15] Diflufenican has shown control over: wild radish, wild turnip, turnip weed,[6] multiply herbicide resistant waterhemp[7] (applied pre-emergence), hedge mustard, Indian hedge mustard, charlock, deadnettle, prickly lettuce, pheasant's eye,[11] Galium aparine, ivy-leaved speedwell and Veronica persica;[10] and suppression of capeweed, crassula, night-scented stock, marshmallow, corn gromwell, chickweed, hyssop loosestrife, Skeleton weed, speedwell, amsinckia, Paterson's curse, rough poppy, sorrel, toad rush, stinging nettle and shepherd's purse.

[11] Diflufenican has been sold in formulations containing (not limited to): isoproturon, ioxynil, mecoprop, bromoxynil, diclofop-methyl,[3] and pendimethalin.

[11] Diflufenican has been applied to crops, including: wheat, barley,[3] field peas, lentils, lupins and oilseed poppy.