After completing his secondary schooling, Ghosh claims to have pursued diploma in engineering from a polytechnic college in Jhargram over an affidavit filed with the Election Commission of India, a case regarding the matter was filed in the Calcutta High Court but the court dismissed it on the grounds that public interest litigation can not be regarding a person's educational qualification.

[13] Ghosh made his electoral debut in 2016 contesting the West Bengal Legislative Assembly from Kharagpur Sadar.

He won in the Kharagpur Sadar constituency of Paschim Medinipur district by defeating his nearest rival Gyan Singh Sohanpal, an Indian National Congress candidate.

Gyan Singh Sohanpal of Congress had won the Kharagpur Sadar assembly seat seven times in a row from 1982 to 2011.

[14] In September 2016, Ghosh went for a seven-day trip to the US, to highlight oppression of the Hindus in West Bengal and infiltration of Muslims from Bangladesh; other speakers in the programme were Subramanian Swamy and Hukum Singh.

[22] Soon after reappointment, he remarked that West Bengal has turned into hub of anti-nationals activities under the governance of Trinamool Congress.

[34][35][36] In September 2019, terming the students of Jadavpur University "anti-nationals" and "terrorists", he insinuated that his party would conduct a "Balakot-like surgical strike" on the JU campus to drive out the communists.

But the foreign cows do not have it," he said while addressing a gathering at an event Gopa Ashtami Karyakram organised by him and Gavikalyan Samity at Burdwan.

[55] He raised questions that why nobody was falling ill or dying at Shaheen Bagh protests, at an event organised by the Kolkata Press Club.

"[58] Dilip Ghosh, who is famous for his controversial remarks, made below-the-belt attacks on the incumbent Chief Minister during his election campaign in 2021.

[70] During the 2021 election campaign, Dilip Ghosh made provocative remarks while Model Code of Conduct was in force, which created grounds for violence.

The claim that consumption of cow urine can cure coronavirus drew sharp criticism from the ruling Trinamool Congress.

[73][74] In September 2020, Dilip Ghosh declared that the coronavirus pandemic had ended and Chief Minister Mamata Banerjee imposed a lockdown on the state to prevent the BJP party from holding public meetings in a packed rally.