She has been a member of the comedy cabaret trio Fascinating Aïda since its 1983 inception, and has also pursued a solo career.

At the age of eighteen, she was expelled for going to see Fellini's Satyricon in London with boys from Worth School.

[citation needed] Keane continued her acting career, including touring versions of Dancing at Lughnasa and Charley's Aunt, Juno and the Paycock at the Leicester Haymarket; The Plough and the Stars at the West Yorkshire Playhouse in Leeds; Accommodating Eva at the King's Head Theatre in Islington and Present Laughter at Birmingham Repertory Theatre.

She appeared with Kit and The Widow in Tomfoolery during 2005 and in the premiere one night only staging of a new musical version of Little Women at the Theatre Royal, Drury Lane.

[citation needed] In 2006, Keane appeared with Jenny Eclair and Linda Robson, in Grumpy Old Women Live, and as the Duchess in Me and My Girl (2006) on a new national tour.

Keane has written and presented on radio for shows such as Stop the Week, 4th Column, Booked!

"[10] In the local elections of 2017, she stood as a candidate for the Liberal Democrats in the Ploughley division of Oxfordshire County Council.

[12] In 2009, Keane was made an honorary Doctor of Letters by the University of Portsmouth, in recognition of her musical career and her links with the city.