[1][2] By deejaying and collaborating, Francis helped to popularize the moombahton genre, and in 2012 he adapted it further into moombahcore and EDM trap, giving the music a harder sound, as heard on his extended play (EP), Something, Something, Awesome.

[3] His 2018 single, "Sexo" (with Residente featuring iLe), peaked at number 43 on the Billboard Latin Airplay chart.

[5] Francis first rose to fame after gaining the attention of American producer Diplo and eventually collaborating on the song "Que Que", with featured Latin-pop artist Maluca.

[19] On March 22, 2014, Francis announced via his official Twitter account that his debut album, titled Money Sucks, Friends Rule,[20] would be released on October 28, 2014, on Mad Decent and Columbia Records.

[21] In August, Dillon released his second single off of the album, which was a collaboration with Sultan + Ned Shepard featuring The Chain Gang of 1974.

On January 1, 2015, Francis revealed to Australian radio station Triple J that he was working on a sketch show pilot for MTV.

The EP features collaborations from Skrillex, Calvin Harris, Chromeo, Bro Safari, and Kygo with James Hersey, along with a remix of "I Can't Take It" from his album Money Sucks, Friends Rule by Party Favor.

He also appeared in the first season of Taskmaster US alongside Lisa Lampanelli, Freddie Highmore, Ron Funches and Kate Berlant.

Dillon Francis released a seven-episode comedy series titled Like and Subscribe in 2018, available exclusively on Funny or Die and Amazon Video.

The show follows Skyy Goldwynne (Dillon Francis), Hollywood's biggest manager who locks 4 of his influencer clients in a house with a camera crew.

On December 7, 2018, Francis released "LFGD" featuring Chris Melberger as part of Astralwerks' compilation album with livestreamer Ninja, Ninjawerks Volume 1.

[29] In 2023, Francis released a collaboration song titled "Free" with Swedish DJ and producer Alesso and English singer-songwriter Clementine Douglas.

[30] Francis stated that the purpose of the song was to promote happiness, dedicating it to listeners who "[want] to feel like a golden retriever living the best day of its life.