They run the record label Smash the House which was founded in 2010, and have collaborated with artists that include Afrojack, Armin van Buuren, Daddy Yankee, David Guetta, Era Istrefi, Fatboy Slim, Gucci Mane, Hardwell, Martin Garrix, Paris Hilton, Steve Angello, Sebastian Yatra and Kid Ink, and have remixed artists such as Lady Gaga, the Chainsmokers and (G)I-dle.

[5] In 2010, after founding their own record label Smash the House, they were tasked with writing the official anthem for the 2010 edition of Tomorrowland, "Tomorrow (Give in to the Night)".

[9] "The Hum" was quickly followed by the release of "Higher Place" (featuring Ne-Yo) which also peaked at number one in Belgium, both songs also certified platinum in the duo's home country.

[11] 2017 saw the release of their platinum selling single "Complicated", certifying in both Belgium[13] and The Netherlands,[14] in addition to their long-awaited festivals gimmick "Crowd Control".

[21] On 15 February 2019, Dimitri Vegas & Like Mike and Era Istrefi released "Selfish"[22] which achieved the number one position on the Billboard Dance Chart.

[24] The music video for the single featured a number of known personalities including YouTubers Nikita Dragun, Vitaly Zdorovetskiy and Juanpa Zurita, singer-songwriter Chester Lockhart, former UFC fighter Chuck Liddell and Kim Kardashian.

[25] Later in 2019, they achieved their first 2× platinum single with "Instagram",[26] a collaboration with David Guetta, Daddy Yankee, Afro Bros and Natti Natasha.

On 5 February 2021, Dimitri Vegas & Like Mike released a remixed version of "Hwaa" by (G)I-dle, a South Korean kpop girl group.

[29][30] In August 2021, the duo collabed with mobile battle royale game "Garena Free Fire", under the collab game has released playable characters based on the duo in-game, official announcement was made by Garena Free Fire's official social media handles on 4 August 2021.

[31] Dimitri Vegas & Like Mike had also previously released track for in-game event "Rampage" of Garena Free Fire in July 2021.

[32] On 20 August 2021, Dimitri Vegas & Like Mike along with Alok and KSHMR released collaboration song for the Garena Free Fire's 4th anniversary.

In July 2023, the duo announced the forthcoming release of their debut studio album Rewind + Repeat, which will feature the single "She Knows" with David Guetta, Afro Bros and Akon.

Vegas has also appeared in several feature films that include Jurassic World: Dominion, The Bouncer, Men in Black: International, Rambo: Last Blood, Yummy, H4Z4RD and It's a Wonderful Knife.