[2][9] Ancient remains at the site attest to a long-time human settlement there;[citation needed] during the Mamluk era, the town was the home of the Bani Jabir tribe.

Ancient remains found throughout the village, including marble and granite columns as well as pottery, attest to longtime settlement at the site.

[10] Following the conquest of the Crusader states during the period of Mamluk rule (1270-1516 CE) over the region of Syria (Levant), Dimra was located on an eastward route which left the main Gaza-Jaffa highway at Beit Hanoun.

[2] According to Moshe Sharon, Dimra was a likely resting place for those travelling in the region due to its natural, independent water supply.

[2] Three pieces of a marble slab, deposited since 1930 in the Rockefeller Museum, and dated to 676 AH (1277 CE) commemorates the building of a mosque at Dimra at that year.

[12] During the 17th and 18th centuries, the area of Dimra experienced a significant process of settlement decline due to nomadic pressures on local communities.

[8] During the 1948 Arab-Israeli war, the women and children of Dimra were reportedly evacuated by the village men on 31 October, likely in response to the advance of the Israeli army.