[5] She has appeared in many high-profile cases, including representing "extraordinary rendition" victim Binyam Mohamed at his Court of Appeal hearing.

[6][7] Rose worked on the judicial review of the Attorney General's decision to drop the investigation into alleged bribes of Saudi officials by BAE Systems.

[16] In February 2020, she was elected President of Magdalen College, Oxford, in succession to Sir David Clary: she is the first woman to hold the position.

[18] In January 2021, Rose was criticised by former Justice of the Constitutional Court of South Africa and Oxford alumnus Edwin Cameron for acting for the Cayman Islands government in a case opposing the legalisation of same-sex marriage.

[20][21][22][23] Whilst Magdalen College's undergraduate body passed a motion affirming its support for her and rejecting calls for her to resign,[24] the university-wide LGBTQ+ Society and African & Caribbean Society released statements condemning what they termed a conflict of interest between her role as president and her role as a barrister.