[2][5][6] The ecology of the park is threatened by encroachment from cattle herders who are being displaced from their traditional grazing lands by the expansion of crop agriculture, through the fundamental cause of expanding regional population.

Populations of migrant grazers, including tiang, Roan, waterbuck and reebuck, are under additional pressure as land outside the park that they migrate across has been converted to farmland.

Game counts between 1971 and 2001 have shown a precipitous decline in most large mammal species, with the population of waterbuck falling by 85%, reedbuck by 72%, and oribi by 68%.

Other species have been extirpated in Dinder since was gazetted, including African bush elephant, black rhinoceros, hippopotamus, tora hartebeest, Nubian giraffe, Soemmerring's gazelle, and the Nile crocodile.

[3] Dinder National Park has been a habitat for the painted hunting dog (Lycaon pictus), but this endangered canid declined in this region.