[1] She played in the UAAP during her collegiate years for the NU Lady Bulldogs and started her professional career in the Philippine Super Liga as the first overall pick in the 2014 season for Petron Blaze Spikers.
[citation needed] Her brother (Axel Leonard, a former member of the men's volleyball varsity team of National University "NU Bulldogs") is currently working in PLDT and her older sister is working in Dubai, while she and her sister, Jaja (now Sachi Minowa), are both playing for various women's volleyball club teams in different leagues.
She is one of the Guest Player especially in Championship match against Cagayan Valley Lady Rising Suns during the 10th Season of Shakey's V - League in the 2013 Open Conference as Smart-Maynilad Net Spikers finished in the second place.
Her first professional team, where she was the first draft pick for the 2014 season with Petron Blaze Spikers[8][9] and debuted in the 2014 All-Filipino Conference of the Philippine Super Liga (PSL).
[12] On August 18, 2016, Santiago announced that she will join the Foton Tornadoes for the 2016 PSL Grand Prix Conference, playing alongside her sister, Jaja.