Fieri travels around the United States, Canada, and Mexico, looking at various diners, drive-in restaurants, and dive bars.

He has also featured restaurants in European cities, including London and Florence, as well as in Cuba and Puerto Rico (see the episodes page).

The host interacts with both the customers, to get their opinion on the food, and with the kitchen staff, who demonstrate how to prepare multiple star dishes on their menus.

[6] The show has had various stars appear in the kitchen alongside Guy Fieri, including fellow chefs Robert Irvine, Andrew Zimmern, Michael Symon, Emeril Lagasse, and Geoffrey Zakarian, as well as celebrities such as Matthew McConaughey, Gene Hackman, Rosie O'Donnell, Joe Theismann, Chris Rock, Kid Rock, Adam Sandler, Kevin James, Clint Bowyer, Martin Sheen, Gene Simmons, Steve Harwell, E-40 and Mick Fleetwood.

[7] A week after Food Network counter-sued the producer, a settlement was reached in August 2011, allowing the 12th season of the show to resume, with a new production company, Citizen Pictures.