The first Protestant missionaries arrived in 1706 with Bartholomäus Ziegenbalg and Heinrich Plütschau of the Lutheran Missions who landed at Tranquebar on the eastern coast of Tamil Nadu.

Once the Wesleyan Methodist Missionary Society set foot in the erstwhile Hyderabad State in 1878,[2] the missionaries led by Henry Little, William Burgess and the Indian Evangelist Benjamin Wesley[2] who pioneered the spread of the Gospel and helped in establishing of churches in areas northward of Hyderabad City winning of new converts to the fold of Christianity.

Meanwhile, efforts were made by visionary Pastors to form the Church of South India for which missionary societies came forward for negotiations who included[16] Anglicans, Baptists, Congregationalists, Lutherans, and Wesleyan Methodists.

First, candidates are admitted to the Diocese of Medak and attached with a Priest in congregations and after a year or two they are sent for ministerial formation to a seminary affiliated to the Senate of Serampore College (University).

Some of its Clergy who have been sent on lien to teach in such spiritual formation centres include, The Bishops that have led the Diocese of Medak were notable and exemplary and having focused on the objective of the Mission and Evangelism as shown through the Gospels.