As of 2013[update], the Diocese of Saginaw had 113 priests, 19 permanent deacons, 122 religious, 18 pastoral administrator, 261 commissioned lay ministers, and 24 seminarians.

The Saginaw Diocese is located in Central Michigan and The Thumb and consists of eleven counties, covering 6,955 square miles (18,010 km2).

The northernmost point of his travels, Saginaw was considered a wilderness community of about 30 people, compared to Detroit which had 3,000 inhabitants.

Murphy purchased an episcopal residence and a chancery office, and appointed officials needed for the administration of the diocese: vicar-general, chancellor, deans of the four districts, secretary, marriage tribunal personnel.

For the large migrant and resident Spanish-speaking population, Murphy established the Guadalupe Clinic and the Mexican Apostolate, and for the elderly, the St. Francis Home.

In 1956, the Capuchin Fathers agreed to erect Queen of Angels Retreat House to serve lay residents and priests of the area.

Woznicki died in 1968, and was succeeded by Bishop Francis Reh, previously rector of the Pontifical North American College in Rome.

Reh transformed the quota system for diocesan support into a Catholic Services Appeal directly to parishioners for their voluntary contributions.

The diocese has also implemented a series of Saint Andrew dinners to invite young men to an informal meal and discussion on vocations.

In 2007 the diocese began an evangelization initiative to reach out to all families in the diocese through the Faith Saginaw magazine,[7] sent a group of 230 people to the March for Life in Washington, D.C.,[8] and held a four-day Eucharistic Congress that summer which included the ordination of two men to the priesthood, and five men to the transitional diaconate.

[9] In March 2018, Saginaw police executed a search warrant at Cistone's residence along with the chancery and cathedral rectory.

Early in 2020, as a result of the COVID-19 outbreak, Bishop Gruss suspended mass throughout the diocese to prevent the spread of the virus.

Gruss switched over to broadcasting Mass from the Cathedral of Mary of the Assumption via WNEM TV 5 and other Saginaw news outlets.

However, drinking fountains were disabled, mandatory hand sanitizer stations maintained, masks for the non-vaccinated remained, and the suspension of altar servers.

In autumn 2021, altar servers were permitted to assist the pastor again, communion stations were returned to their original pre-pandemic settings, minus the serving of the chalices containing the Blood of Christ, and pews still cordoned off were opened up again.

Also, with it being almost three years since the COVID restrictions started to be eased, Mass at the various churches in the Diocese have fully returned to their pre-pandemic settings as both the Body and Blood of Christ is served at Communion again, boys and girls of appropriate age have started volunteering to aid the pastors again as altar servers, water fountains are restarted, all pews are opened, and hand sanitizer stations are still available.

Heames was parochial administrator at St. Mary University Parish in Mount Pleasant until the diocese removed him in July 2015 for "boundary violations".

[18] In November 2018, the diocese released a list of 18 deceased priests with credible accusations of sexual abuse of a minor.

[19] In April 2018, the diocese asked retired Michigan Appeals Court Judge Michael Talbot to conduct an investigation into its sexual abuse allegations.

[20] James Aloysius Hickey (1967–1974), appointed Bishop of Cleveland and later Archbishop of Washington (elevated to cardinal in 1988) The coat of arms for the Diocese of Saginaw shows a cross in red on a silver field.