It is a suffragan diocese of the Archdiocese of San Pedro Sula.

Formerly in the Diocese of Tegucigalpa, Yoro was formed due to the extent of the territory covered, under papal order by Benedict XVI on 18 September 2005.

The Canadian priest Juan Luis Giasson, was made Bishop.

On the death of Bishop Juan Luis Giasson, Pope Francis appointed Hector David Garcia Osorio as senior official of the diocese on July 3, 2014.

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