Deodato Guinaccia

was an Italian painter of the Renaissance period, active mainly in Messina, Sicily.

In Messina, he became the pupil of the painter Polidoro da Caravaggio, who had moved there after the 1528 Sack of Rome.

Guinaccia painted the Trinity for the church of the Confraternita de Pellegrini in Messina.

He painted a Transfiguration for the church of San Salvatore de Greci.

Among the pupils of Guinaccia in Messina were Cesare di Napoli, Francesco and Giovanni Simone Comande, and Antonio Catalano the Elder.