Having helped them gain promotion to the Premier League, he joined the club in 2018 for a reported €14 million and went on to make 131 appearances for them, scoring 44 goals.

[10] Jota first appeared in the Primeira Liga on 20 February 2015, coming on as a late substitute for Diogo Rosado in a 2–2 home draw against Vitória de Guimarães.

[14] In the first game of the campaign, a 1–0 win over Académica at the Estádio da Mata Real on 17 August, he was sent off at the end for pushing Hugo Seco; Ricardo Nascimento was also sent off for retaliating on his teammate's behalf.

[18] Jota also took part in the 2016–17 UEFA Champions League, scoring his first goal in the competition on 7 December in a 5–0 home victory against Leicester City.

[53] On 3 November, he opened the scoring in a 2–0 home victory in the Champions League against his former club Atlético Madrid to ensure Liverpool's qualification to the round of 16, as group winners.

[57] On 20 January 2022, in the second leg of the EFL Cup semi-finals, Jota scored both goals in a 2–0 away win over Arsenal to send Liverpool into the final.

[58] On 27 February, following a goalless draw against Chelsea after extra time, he scored his penalty during the shoot-out to help Liverpool win their first League Cup since 2012.

[62] On 28 May, Jota made a substitute appearance in the 65th minute of the 2022 UEFA Champions League Final, as Liverpool lost to 1–0 Real Madrid.

[65] He made his return from injury on 3 September, replacing Darwin Núñez in the 80th minute of a 0–0 draw against rivals Everton in the Merseyside derby.

[67] On 16 October, he suffered a calf injury during Liverpool's 1–0 home win over Manchester City, which ruled him out for the 2022 FIFA World Cup.

He would receive criticism from pundits; Stephen Warnock claimed that he had "been poor since coming on at half time, not up to the pace of the game at all", while Gary Neville agreed with the red card, as he believed Jota's actions were a "stupidity".

[76] In January 2024, with the absence of Mohamed Salah in the 2023 Africa Cup of Nations and his subsequent injury, Jota stepped up in absence, forming a successful partnership with Darwin Núñez, with scoring five goals and assisting another two in Liverpool's wins over Burnley, Newcastle United, Bournemouth and Chelsea, earning him the Premier League Player of the Month award for January.

[81] Shortly after, Jota suffered another injury setback against Fulham on 21 April, leading him to miss Liverpool's remaining matches of the 2023–24 season.

[85] Jota started playing for Portugal at under-19 level,[86] scoring his first goal on 29 May 2015 in a 6–1 home win over Turkey in 2015 UEFA European Under-19 Championship qualification.

[89] In March 2019, Jota was called up to the senior side for the first time, ahead of the opening UEFA Euro 2020 qualifying matches against Ukraine and Serbia.

[93] Jota was named in Portugal's final squad for the delayed UEFA Euro 2020 tournament, scoring in a 4–2 group stage defeat to Germany.

[68] On 11 September 2023, Jota scored a brace in Portugal's 9–0 home defeat of Luxembourg in the UEFA Euro 2024 qualifiers, their biggest win in international history.

[102] Jota is also known for his clinical finishing, explosive pace, dribbling ability, positional sense, movement and close control which make him especially effective on the counter-attack.

[107] During the lockdown during the COVID-19 pandemic he took part in an invitational series of FIFA matches, run by the Premier League, eventually beating future teammate Trent Alexander-Arnold in the final of the competition.